Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones - Normandie Université Access content directly
Journal Articles Organic Letters Year : 2015

Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones

Abstract

An unprecedented multicomponent organocatalyzed Knoevenagel–aza-Michael–cyclocondensation reaction between Meldrum’s acid, hydroxylamines, and aldehydes afforded a straightforward entry to a large array of racemic and syn-diastereoenriched isoxazolidinones as synthetically useful scaffolds. This process revealed a markedly facile aza-Michael–cyclocondensation sequence as a key domino reaction between RCO2NHOH and transient alkylidene Meldrum’s acid upon Brønsted base catalysis.
No file

Dates and versions

hal-02046141 , version 1 (22-02-2019)

Identifiers

Cite

Christophe Berini, Muriel Sebban, Hassan Oulyadi, Morgane Sanselme, Vincent Levacher, et al.. Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones. Organic Letters, 2015, 17 (21), pp.5408-5411. ⟨10.1021/acs.orglett.5b02755⟩. ⟨hal-02046141⟩
23 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More