Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents - Université de Rouen Normandie Accéder directement au contenu
Article Dans Une Revue RSC Advances Année : 2017

Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents

Résumé

A series of hitherto unknown acyclic 5,5-difluoro-5-phosphono-pent-2-en-1-yl-pyrimidines (9a, b, 13a, b), -purines (16a, b) and -(1,2,4)-triazolo-3-carboxamide (19) were successfully synthesized from (E)-1-bromo-5-diethoxyphosphoryl-5,5-difluoro-pent-2-ene in a stereoselective manner. All the synthetized compounds were assayed for antiviral activity against various viruses, but were found to be neither active nor toxic.

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Chimie organique
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hal-01829613 , version 1 (27-05-2024)

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Florian Chevrier, Zein Chamas, Thierry Lequeux, Emmanuel Pfund, G. Andrei, et al.. Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents. RSC Advances, 2017, 7 (51), pp.32282 - 32287. ⟨10.1039/c7ra05153k⟩. ⟨hal-01829613⟩
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