A new 2-hit model combining serine racemase deletion and 3 maternal separation displays behavioral and cognitive 4 deficits associated with schizophrenia - Ethologie animale et humaine Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2024

A new 2-hit model combining serine racemase deletion and 3 maternal separation displays behavioral and cognitive 4 deficits associated with schizophrenia

Résumé

Schizophrenia (SCZ) is a multifactorial psychotic disorder characterized by positive and negative symptoms as well as cognitive impairments. To advance the current treatments, it is important to improve animal models by considering the multifactorial etiology, thus by combining different risk factors. The objective of our study was to explore in a a new mouse model, the impact of genetic deletion of serine racemase (genetic vulnerability) combined with an early stress factor induced by maternal separation (early environmental exposure) in the context of SCZ development. The face validity of the model was assessed through a wide range of behavioral experiments. The 2-hit mice displayed an increased locomotor activity mimicking positive symptoms, working memory impairment, cognitive deficits and recognition memory alterations, which could reflect neophobia. This new multifactorial model therefore presents an interesting phenotype for modelling animal model with behavioral and cognitive deficits associated with SCZ.
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Dates et versions

hal-04627091 , version 1 (27-06-2024)

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  • HAL Id : hal-04627091 , version 1

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Jean-Marie Billard, Caroline Lahogue, Michel Boulouard, François Menager, Thomas Freret, et al.. A new 2-hit model combining serine racemase deletion and 3 maternal separation displays behavioral and cognitive 4 deficits associated with schizophrenia. 2024. ⟨hal-04627091⟩
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