Comparison of the Prevalence of Meal‐Related Nausea in Different Functional Dyspepsia Subgroups
2 UZ Leuven - Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain
3 GU - Göteborgs Universitet = University of Gothenburg
4 Gastroenterology Department of Wuhan Union, Tongji Medical College of Huazhong Science and Technology University, Wuhan, China.
5 ADEN - Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
6 IRIB - Institute for Research and Innovation in Biomedicine
7 UNIROUEN - Université de Rouen Normandie
8 CIC Rouen - Centre d'Investigation Clinique [CHU Rouen]
9 Service d'Hépato-Gastroentérologie [CHU Rouen]
10 Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice [CHU Rouen]
11 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
12 NUS - National University of Singapore
13 Univerzita Komenského = Comenius University [Bratislava]
14 Department of Gastroenterology and Hepatology of Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia.
15 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
16 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
17 Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
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Résumé
ABSTRACT Background Nausea can coexist in functional dyspepsia (FD) but the literature is poor in reporting whether this symptom is mainly triggered by meal ingestion. Moreover, the prevalence of nausea in FD is understudied. Methods Adult patients with a disorder of gut–brain interaction (DGBI) recruited in secondary and tertiary care facilities completed the enhanced Asian Rome IV questionnaire with additional questions to address the relationship between nausea and food intake. A comparison of nausea and the prevalence of meal‐related nausea was made among FD subgroups and with chronic nausea and vomiting syndrome (CNVS), both according to Rome IV criteria. Key Results Of the 1075 DGBI patients that completed the survey, 443 were classified as having FD and 44 other patients fulfilled diagnostic criteria for CNVS. The PDS‐EPS overlap group had a higher prevalence of nausea compared to PDS and EPS patients. In PDS patients with nausea, nausea was significantly more often meal‐related (than in PDS‐EPS overlap, EPS, and CNVS patients). All patients with meal‐related nausea reported that nausea started mostly (> 85% of times) within 60 min after the meal. When comparing western and eastern participating centers, nausea was more prevalent in patients from western sites. Conclusions and Interferences Nausea is a highly prevalent symptom in FD with a higher prevalence in the PDS–EPS overlap group. However, meal‐related nausea is more common in PDS. The pathophysiology of nausea in FD and its implication for medical treatment require further studies.
