C2254 in ORF30 and G713 in ORF11, two EHV-1 variants of interest, what happened to them?
Résumé
Background: Varicellovirus equidalpha1 (EHV-1) is an endemic horse pathogen worldwide responsible of respiratory epidemics, abortions and myeloencephalopathy (EHM). Since 2019, EHM epizooties have been described and for some of them, the reports focus on two variants identified by a specific nucleotide mutation: C2254, because this position in ORF30 is receiving particular attention from the scientific community and G713 in ORF11 because this nucleotide was used as a tracer during and after an important EHM outbreak in Europe (Valencia, Spain).
Objectives: To identify the presence of C2254 and G713 mutations since 2019.
Study design: Laboratory surveillance and literature survey.
Main limitations: Lack of whole genomes to compare these 2 variants.
Ethical animal research: Not required: analysis of microorganisms.
Informed consent: Not stated.
Competing interests: None declared.
Funding: LABEO.