<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04635900</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T15:37:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells</title>
            <author role="aut">
              <persName>
                <forename type="first">Antonio</forename>
                <surname>Zandona</surname>
              </persName>
              <idno type="halauthorid">1805272-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Josip</forename>
                <surname>Madunić</surname>
              </persName>
              <idno type="halauthorid">3188806-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Katarina</forename>
                <surname>Miš</surname>
              </persName>
              <idno type="halauthorid">3188807-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nikola</forename>
                <surname>Maraković</surname>
              </persName>
              <idno type="halauthorid">3188808-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Dubois-Geoffroy</surname>
              </persName>
              <idno type="halauthorid">3188809-0</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marco</forename>
                <surname>Cavaco</surname>
              </persName>
              <idno type="halauthorid">3188810-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Petra</forename>
                <surname>Mišetić</surname>
              </persName>
              <idno type="halauthorid">1805270-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jasna</forename>
                <surname>Padovan</surname>
              </persName>
              <idno type="halauthorid">3188811-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Miguel</forename>
                <surname>Castanho</surname>
              </persName>
              <idno type="halauthorid">2718185-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ludovic</forename>
                <surname>Jean</surname>
              </persName>
              <idno type="halauthorid">14591-0</idno>
              <affiliation ref="#struct-1004757"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Yves</forename>
                <surname>Renard</surname>
              </persName>
              <email type="md5">f3d88d106e14d53dd98baf0f830acecb</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">pierre-yves-renard</idno>
              <idno type="idhal" notation="numeric">178108</idno>
              <idno type="halauthorid" notation="string">2534153-178108</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABG-9624-2021</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9094-9778</idno>
              <idno type="IDREF">https://www.idref.fr/122924029</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/ABG-9624-2021</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sergej</forename>
                <surname>Pirkmajer</surname>
              </persName>
              <idno type="halauthorid">2032535-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vera</forename>
                <surname>Neves</surname>
              </persName>
              <idno type="halauthorid">717795-0</idno>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Maja</forename>
                <surname>Katalinić</surname>
              </persName>
              <email type="md5">bc6ba252109de8403af5623bb7e38288</email>
              <email type="domain">imi.hr</email>
              <idno type="idhal" notation="numeric">1397952</idno>
              <idno type="halauthorid" notation="string">1805276-1397952</idno>
              <affiliation ref="#struct-1077325"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierre-Yves</forename>
                <surname>renard</surname>
              </persName>
              <email type="md5">f3d88d106e14d53dd98baf0f830acecb</email>
              <email type="domain">univ-rouen.fr</email>
            </editor>
            <funder ref="#projanr-25520"/>
            <funder ref="#projanr-54803"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-07-04 19:21:21</date>
              <date type="whenModified">2025-05-15 03:09:32</date>
              <date type="whenReleased">2024-07-08 14:30:34</date>
              <date type="whenProduced">2023-08</date>
              <date type="whenEndEmbargoed">2024-07-04</date>
              <ref type="file" target="https://normandie-univ.hal.science/hal-04635900v1/document">
                <date notBefore="2024-07-04"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://normandie-univ.hal.science/hal-04635900v1/file/Zandona%20et%20al_23-2-2023.pdf" id="file-4635900-4024458">
                <date notBefore="2024-07-04"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="69085">
                <persName>
                  <forename>Pierre-Yves</forename>
                  <surname>renard</surname>
                </persName>
                <email type="md5">f3d88d106e14d53dd98baf0f830acecb</email>
                <email type="domain">univ-rouen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04635900</idno>
            <idno type="halUri">https://normandie-univ.hal.science/hal-04635900</idno>
            <idno type="halBibtex">zandona:hal-04635900</idno>
            <idno type="halRefHtml">&lt;i&gt;Toxicology&lt;/i&gt;, 2023, 494, pp.153588. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.tox.2023.153588"&gt;&amp;#x27E8;10.1016/j.tox.2023.153588&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Toxicology, 2023, 494, pp.153588. &amp;#x27E8;10.1016/j.tox.2023.153588&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4635900-4024458"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INSA-ROUEN">Institut National des Sciences Appliquées de Rouen</idno>
            <idno type="stamp" n="ENSI-CAEN">Ecole Nationale Supérieure d'Ingénieurs de Caen</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="ENSICAEN">École Nationale Supérieure d’Ingénieurs de Caen</idno>
            <idno type="stamp" n="UNILEHAVRE">Université Le Havre Normandie</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="COBRA" corresp="CNRS">Chimie Organique et Bioorganique : Reactivité et Analyse </idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="LABOS-XL-CHEM">École Universitaire de Recherche (EUR) XL-Chem</idno>
            <idno type="stamp" n="PUBLIS-XL-CHEM">Publications financées par l'EUR XL-CHEM</idno>
            <idno type="stamp" n="LABOS-SYNORG">Labex SYNORG</idno>
            <idno type="stamp" n="PUBLIS-SYNORG">Publications financées par le Labex SYNORG</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Antonio</forename>
                    <surname>Zandona</surname>
                  </persName>
                  <idno type="halauthorid">1805272-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Josip</forename>
                    <surname>Madunić</surname>
                  </persName>
                  <idno type="halauthorid">3188806-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Katarina</forename>
                    <surname>Miš</surname>
                  </persName>
                  <idno type="halauthorid">3188807-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nikola</forename>
                    <surname>Maraković</surname>
                  </persName>
                  <idno type="halauthorid">3188808-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Dubois-Geoffroy</surname>
                  </persName>
                  <idno type="halauthorid">3188809-0</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marco</forename>
                    <surname>Cavaco</surname>
                  </persName>
                  <idno type="halauthorid">3188810-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Petra</forename>
                    <surname>Mišetić</surname>
                  </persName>
                  <idno type="halauthorid">1805270-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jasna</forename>
                    <surname>Padovan</surname>
                  </persName>
                  <idno type="halauthorid">3188811-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Miguel</forename>
                    <surname>Castanho</surname>
                  </persName>
                  <idno type="halauthorid">2718185-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ludovic</forename>
                    <surname>Jean</surname>
                  </persName>
                  <idno type="halauthorid">14591-0</idno>
                  <affiliation ref="#struct-1004757"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Yves</forename>
                    <surname>Renard</surname>
                  </persName>
                  <email type="md5">f3d88d106e14d53dd98baf0f830acecb</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">pierre-yves-renard</idno>
                  <idno type="idhal" notation="numeric">178108</idno>
                  <idno type="halauthorid" notation="string">2534153-178108</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABG-9624-2021</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9094-9778</idno>
                  <idno type="IDREF">https://www.idref.fr/122924029</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/ABG-9624-2021</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sergej</forename>
                    <surname>Pirkmajer</surname>
                  </persName>
                  <idno type="halauthorid">2032535-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vera</forename>
                    <surname>Neves</surname>
                  </persName>
                  <idno type="halauthorid">717795-0</idno>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Maja</forename>
                    <surname>Katalinić</surname>
                  </persName>
                  <email type="md5">bc6ba252109de8403af5623bb7e38288</email>
                  <email type="domain">imi.hr</email>
                  <idno type="idhal" notation="numeric">1397952</idno>
                  <idno type="halauthorid" notation="string">1805276-1397952</idno>
                  <affiliation ref="#struct-1077325"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21180</idno>
                <idno type="issn">0300-483X</idno>
                <title level="j">Toxicology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">494</biblScope>
                  <biblScope unit="pp">153588</biblScope>
                  <date type="datePub">2023-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.tox.2023.153588</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">cell viability</term>
                <term xml:lang="en">pharmacophore</term>
                <term xml:lang="en">apoptosis</term>
                <term xml:lang="en">oximes</term>
                <term xml:lang="en">antidotes</term>
                <term xml:lang="en">antidotes oximes apoptosis pharmacophore cell viability</term>
              </keywords>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The uncharged 3-hydroxy-2-pyridine aldoximes with protonatable tertiary amines are studied as antidotes in toxic organophosphates (OP) poisoning. Due to some specific structural features they have, we hypothesize that these compounds could exert diverse biological activity beyond their main scope of application. To examine this further,we performed an extensive cell-based assessment to determine their effects on human cells and possible mechanism of action. As our results indicated, in the concentration range up to 800 μM, aldoxime having piperidine moiety did not induce significant toxicity, while those with tetrahydroisoquinoline moiety stimulated mitochondria-mediated activation of the intrinsic apoptosis pathway through ERK1/2 and p38-MAPK signaling and subsequent activation of initiator caspase 9 and executive caspase 3 accompanied with DNA damage. Mitochondria and fatty acid metabolism were also likely targets of 3-hydroxy-2-pyridine aldoximes, due to increased phosphorylation of acetyl-CoA carboxylase. In silico analysis predicted kinases as their most probable target class, while pharmacophores modelingadditionaly predicted the inhibition of a cytochrome P450cam, as well. Overall, observed biological activity of aldoximes with tetrahydroisoquinoline moiety could be indicative for future design of compounds either in a negative context in OP antidotes design, or in a positive one for design of compounds for the treatment of other conditions and diseases, such as cancer.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-141329" status="OLD">
          <idno type="IdRef">147289319</idno>
          <idno type="RNSR">200012115Y</idno>
          <idno type="ROR">https://ror.org/04e8pda19</idno>
          <orgName>Chimie Organique et Bioorganique : Réactivité et Analyse</orgName>
          <orgName type="acronym">COBRA</orgName>
          <date type="start">2000-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>1 Rue Tesniere 76821 Mont St Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lab-cobra.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-106625" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-441569" type="direct"/>
            <relation active="#struct-302261" type="direct"/>
            <relation active="#struct-7127" type="indirect"/>
            <relation active="#struct-246955" type="indirect"/>
            <relation active="#struct-300317" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="FR3038" active="#struct-441569" type="direct"/>
            <relation name="UMR6014" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004757" status="VALID">
          <idno type="RNSR">200012689X</idno>
          <idno type="ROR">05cbrk226</idno>
          <orgName>Cibles Thérapeutiques et conception de médicaments</orgName>
          <orgName type="acronym">CiTCoM - UMR 8038</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de pharmacie 4 avenue de l'Observatoire 75006 PARIS</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR 8038" active="#struct-441569" type="direct"/>
            <relation name="UMR 8038" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1077325" status="INCOMING">
          <orgName>IMROH</orgName>
          <desc>
            <address>
              <addrLine>Zagreb</addrLine>
              <country key="HR"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-106625" status="VALID">
          <idno type="IdRef">140056521</idno>
          <orgName>Institut de Chimie Organique Fine</orgName>
          <orgName type="acronym">IRCOF</orgName>
          <desc>
            <address>
              <addrLine>Rue Tesniére 76131 Mont Saint Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lab-cobra.fr/laboratoire/batiment</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301288" status="VALID">
          <idno type="IdRef">033364346</idno>
          <idno type="ISNI">0000000121908462</idno>
          <idno type="ROR">https://ror.org/020ws7586</idno>
          <orgName>Institut national des sciences appliquées Rouen Normandie</orgName>
          <orgName type="acronym">INSA Rouen Normandie</orgName>
          <date type="start">1985-01-01</date>
          <desc>
            <address>
              <addrLine>Avenue de l’Université 76801 Saint-Étienne-du-Rouvray Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-rouen.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-302261" status="VALID">
          <idno type="RNSR">200810697X</idno>
          <orgName>Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire</orgName>
          <orgName type="acronym">INC3M</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>Rue Tesnière76821 MONT ST AIGNAN CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.lcmt.ensicaen.fr/federation-inc3m/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-246955" type="direct"/>
            <relation active="#struct-300317" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="FR3038" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-246955" status="VALID">
          <idno type="IdRef">190907991</idno>
          <idno type="ROR">https://ror.org/01fpqqe90</idno>
          <orgName>École Nationale Supérieure d'Ingénieurs de Caen</orgName>
          <orgName type="acronym">ENSICAEN</orgName>
          <desc>
            <address>
              <addrLine>6, Boulevard du Maréchal Juin CS 45053 14050 CAEN cedex 04</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ensicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300317" status="VALID">
          <idno type="IdRef">031308570</idno>
          <idno type="ISNI">0000000121731046</idno>
          <idno type="ROR">https://ror.org/05v509s40</idno>
          <orgName>Université Le Havre Normandie</orgName>
          <orgName type="acronym">ULH</orgName>
          <date type="start">1984-08-27</date>
          <desc>
            <address>
              <addrLine>25 rue Philippe Lebon - BP 1123 - 76063 Le Havre Cedex France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lehavre.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-25520" status="VALID">
          <idno type="anr">ANR-11-LABX-0029</idno>
          <orgName>SYNORG</orgName>
          <desc>Synthèse Organique : des molécules au vivant</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-54803" status="VALID">
          <idno type="anr">ANR-18-EURE-0020</idno>
          <orgName>XL Chem</orgName>
          <desc>XLChem, Synthesizing our future</desc>
          <date type="start">2018</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>