Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia - Normandie Université
Article Dans Une Revue Viruses Année : 2024

Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia

Charles El-Hage
Kim Jeffers
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Nichol Bamford

Résumé

Reports of newly discovered equine hepatotropic flavi- and parvoviruses have emergedthroughout the last decade in many countries, the discovery of which has stimulated a great dealof interest and clinical research. Although commonly detected in horses without signs of disease,equine parvovirus hepatitis (EqPV-H) and equine hepacivirus (EqHV) have been associated withliver disease, including following the administration of contaminated anti-toxin. Our aim was todetermine whether EqPV-H and EqHV are present in Australian horses and whether EqPV-H waspresent in French horses and to examine sequence diversity between strains of both viruses amongstinfected horses on either side of the globe. Sera from 188 Australian horses and 256 French horsesfrom horses with and without clinical signs of disease were collected. Twelve out of 256 (4.7%)and 6 out of 188 (3.2%) French and Australian horses, respectively, were positive for the moleculardetection of EqPV-H. Five out of 256 (1.9%) and 21 out of 188 (11.2%) French and Australian horses,respectively, were positive for the molecular detection of EqHV. Australian strains for both viruseswere genomically clustered, in contrast to strains from French horses, which were more broadlydistributed. The findings of this preliminary survey, with the molecular detection of EqHV andEqPV-H in Australia and the latter in France, adds to the growing body of awareness regarding theserecently discovered hepatotropic viruses. It has provided valuable information not just in terms ofgeographic endemicity but will guide equine clinicians, carers, and authorities regarding infectiousagents and potential impacts of allogenic tissue contamination. Although we have filled many gapsin the world map regarding equine hepatotropic viruses, further prospective studies in this emergingfield may be useful in terms of elucidating risk factors and pathogenesis of these pathogens andmanagement of cases in terms of prevention and diagnosis.
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Dates et versions

hal-04590424 , version 1 (28-05-2024)

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Christine Fortier, Charles El-Hage, Camille Normand, Erika Hue, Gabrielle Sutton, et al.. Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia. Viruses, 2024, 16, pp.862-875. ⟨10.3390/v16060862⟩. ⟨hal-04590424⟩
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