Efficient and Scalable Protocol for theZ-Selective Synthesis of Unsaturated Esters by Horner Wadsworth Emmons Olefination
Résumé
The synthesis of a highly Z-selective Horner-Wadsworth À Emmons (HWE) reagent from cheap and readily available starting materials on a 200-g scale is described. The HWE reaction conditions have also been studied in order to design an efficient and scalable protocol leading to Z-selectivities close to 95% with aromatic and aliphatic aldehydes.
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Adv Synth Catal - 2005 - Touchard - Efficient and Scalable Protocol for the Z‐Selective Synthesis of Unsaturated Esters by.pdf (108.09 Ko)
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