Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives - Normandie Université
Article Dans Une Revue Molecules Année : 2023

Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives

Résumé

The electrocarboxylation of α,α-dichloroarylmethane derivatives in the presence of CO2 was achieved, providing several α-chloroarylacetic acid derivatives with modest yields but high selectivity (chlorinated vs. non-chlorinated or dicarboxylic acid products). The obtained products were then involved in several chemical transformations, underlining their potential as versatile intermediates in synthetic chemistry. A mechanism was also proposed based upon a control experiment and cyclic voltammetry (CV) study.

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Chimie organique
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Dates et versions

hal-04238834 , version 1 (12-10-2023)

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Corentin Maret, Nicolas David, David Pierrot, Eric Léonel, Vincent Levacher, et al.. Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives. Molecules, 2023, 28 (18), pp.6704. ⟨10.3390/molecules28186704⟩. ⟨hal-04238834⟩
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