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            <idno type="halRefHtml">&lt;i&gt;Equine Veterinary Journal&lt;/i&gt;, 2012, 44 (3), pp.277-281. &lt;a target="_blank" href="https://dx.doi.org/10.1111/j.2042-3306.2011.00421.x"&gt;&amp;#x27E8;10.1111/j.2042-3306.2011.00421.x&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">Serum concentration of surfactant protein D in horses with lower airway inflammation</title>
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                    <forename type="first">Eric</forename>
                    <surname>Richard</surname>
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                    <surname>Christmann</surname>
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                    <forename type="first">Guillaume</forename>
                    <surname>Fortier</surname>
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                <idno type="issn">0425-1644</idno>
                <title level="j">Equine Veterinary Journal</title>
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                  <publisher>Wiley-Blackwell</publisher>
                  <biblScope unit="volume">44</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">277-281</biblScope>
                  <date type="datePub">2012-05</date>
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              <p>Reasons for performing study: Surfactant protein D (SP-D), mainly synthesised by alveolar type II cells and nonciliated bronchiolar cells, is one important component of innate pulmonary immunity. In man, circulating concentrations of SP-D are routinely used as biomarkers for pulmonary injury. To date, serum SP-D levels have only been investigated in horses in an experimental model of bacterial airway infection.Objectives: To compare serum SP-D concentrations at rest and after exercise in horses with and without inflammatory airway disease (IAD).Methods: Venous blood samples were collected from 42 Standardbred racehorses at rest and 60 min after performing a standardised treadmill exercise test. Tracheal wash and bronchoalveolar lavage fluid (BALF) samples were collected after exercise. Based on BALF cytology, 22 horses were defined as IAD-affected and 20 classified as controls. Serum SP-D concentrations were assessed using a commercially available ELISA kit and statistically compared between groups of horses and sampling times.Results: Serum concentrations of SP-D in IAD-affected horses were significantly higher than those of control horses, both at rest and after exercise. Within the IAD-affected group, no significant correlation was found between serum SP-D concentrations and BALF cytology. Within each group of horses (IAD and control), no significant influence of exercise was found on serum SP-D levels.Conclusions: This is the first study determining serum SP-D concentrations in a noninfectious, naturally occurring form of lower airway inflammation in horses. The results highlight that IAD is associated with a detectable, though moderate, increase of circulating SP-D levels.Potential relevance: Serum concentration of surfactant protein D could represent a potentially valuable and readily accessible blood biomarker of equine lower airway inflammation.</p>
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