<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04157315</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-26T12:14:24+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Molecular characterization of Enterococcus faecalis two-component signal transduction pathways related to environmental stresses</title>
            <author role="aut">
              <persName>
                <forename type="first">Yoann</forename>
                <surname>Le Breton</surname>
              </persName>
              <idno type="halauthorid">765850-0</idno>
              <affiliation ref="#struct-52741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gregory</forename>
                <surname>Boel</surname>
              </persName>
              <idno type="halauthorid">2858075-0</idno>
              <affiliation ref="#struct-52741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Abdellah</forename>
                <surname>Benachour</surname>
              </persName>
              <idno type="halauthorid">442012-0</idno>
              <affiliation ref="#struct-52741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Herve</forename>
                <surname>Prevost</surname>
              </persName>
              <idno type="halauthorid">2858076-0</idno>
              <affiliation ref="#struct-302936"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yannick</forename>
                <surname>Auffray</surname>
              </persName>
              <idno type="halauthorid">1901539-0</idno>
              <affiliation ref="#struct-52741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Rincé</surname>
              </persName>
              <email type="md5">4efd44d654959bdb88bca3f2b1e8dbad</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="string">alain-rince</idno>
              <idno type="idhal" notation="numeric">931326</idno>
              <idno type="halauthorid" notation="string">442008-931326</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0165-7288</idno>
              <idno type="IDREF">https://www.idref.fr/077238192</idno>
              <affiliation ref="#struct-52741"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Alain</forename>
                <surname>Rincé</surname>
              </persName>
              <email type="md5">4efd44d654959bdb88bca3f2b1e8dbad</email>
              <email type="domain">unicaen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-07-10 11:23:22</date>
              <date type="whenModified">2026-05-05 13:36:02</date>
              <date type="whenReleased">2023-07-10 11:23:22</date>
              <date type="whenProduced">2003-05</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/WNG-RXRLHDVT-T/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="176625">
                <persName>
                  <forename>Alain</forename>
                  <surname>Rincé</surname>
                </persName>
                <email type="md5">4efd44d654959bdb88bca3f2b1e8dbad</email>
                <email type="domain">unicaen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04157315</idno>
            <idno type="halUri">https://normandie-univ.hal.science/hal-04157315</idno>
            <idno type="halBibtex">lebreton:hal-04157315</idno>
            <idno type="halRefHtml">&lt;i&gt;Environmental Microbiology&lt;/i&gt;, 2003, 5 (5), pp.329-337. &lt;a target="_blank" href="https://dx.doi.org/10.1046/j.1462-2920.2003.00405.x"&gt;&amp;#x27E8;10.1046/j.1462-2920.2003.00405.x&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Environmental Microbiology, 2003, 5 (5), pp.329-337. &amp;#x27E8;10.1046/j.1462-2920.2003.00405.x&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="UNAM">l'unam - université nantes angers le mans</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="ONIRIS">École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes-Atlantique (Oniris)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Molecular characterization of Enterococcus faecalis two-component signal transduction pathways related to environmental stresses</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoann</forename>
                    <surname>Le Breton</surname>
                  </persName>
                  <idno type="halauthorid">765850-0</idno>
                  <affiliation ref="#struct-52741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gregory</forename>
                    <surname>Boel</surname>
                  </persName>
                  <idno type="halauthorid">2858075-0</idno>
                  <affiliation ref="#struct-52741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Abdellah</forename>
                    <surname>Benachour</surname>
                  </persName>
                  <idno type="halauthorid">442012-0</idno>
                  <affiliation ref="#struct-52741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Herve</forename>
                    <surname>Prevost</surname>
                  </persName>
                  <idno type="halauthorid">2858076-0</idno>
                  <affiliation ref="#struct-302936"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yannick</forename>
                    <surname>Auffray</surname>
                  </persName>
                  <idno type="halauthorid">1901539-0</idno>
                  <affiliation ref="#struct-52741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Rincé</surname>
                  </persName>
                  <email type="md5">4efd44d654959bdb88bca3f2b1e8dbad</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="string">alain-rince</idno>
                  <idno type="idhal" notation="numeric">931326</idno>
                  <idno type="halauthorid" notation="string">442008-931326</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0165-7288</idno>
                  <idno type="IDREF">https://www.idref.fr/077238192</idno>
                  <affiliation ref="#struct-52741"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22298</idno>
                <idno type="issn">1462-2912</idno>
                <idno type="eissn">1462-2920</idno>
                <title level="j">Environmental Microbiology</title>
                <imprint>
                  <publisher>Society for Applied Microbiology and Wiley-Blackwell</publisher>
                  <biblScope unit="volume">5</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">329-337</biblScope>
                  <date type="datePub">2003-05</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1046/j.1462-2920.2003.00405.x</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART.DATAPAPER">Journal articles - Data paper</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>A key issue in the comprehension of the Enterococcus faecalis stress response is to understand how this bacterium is able to modulate its gene expression in accordance to environmental conditions. Through bioinformatic analysis of the E. faecalis V583 genome, nine two-component systems and a single orphan response regulator were identified. A transcriptional study gave evidence of four systems whose expression is induced by at least one environmental stress. In addition, gene disruption experiments allowed the isolation of eight response regulator mutants. Insertional inactivation of the response regulator gene err 05 resulted in growth default and cell morphology alterations; and also in expression default of the sagA gene, this latter being recently shown involved in E. faecalis stress resistance toward numerous lethal treatments (Y. Le Breton, A. Mazé, A. Hartke, S. Lemarinier, Y. Auffray and A. Rincé (2002) Current Microbiol 45: 434-439). Disruption of the err 04, err 08 or err 18 genes resulted in sensitivity towards heat. Finally, the err 10 mutant was shown to be more sensitive to acid pH and NaCl whereas its growth was less affected by bile salts or heat. We also demonstrated that the heat resistance phenotype of the err 10 mutant was correlated with an increase of the heat shock proteins DnaK and GroEL level.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-52741" status="OLD">
          <orgName>Laboratoire de Microbiologie de l’Environnement</orgName>
          <orgName type="acronym">LME</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <addrLine>Esplanade de la paix - CS 14032 14032 Caen cedex 5</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="EA 956" active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation name="USC 2017" active="#struct-92114" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-302936" status="VALID">
          <idno type="ROR">https://ror.org/05q0ncs32</idno>
          <orgName>École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique</orgName>
          <orgName type="acronym">Oniris VetAgroBio</orgName>
          <desc>
            <address>
              <addrLine>101 route de Gachet - 44300 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.oniris-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>