Effect of Phthalates and Their Substitutes on the Physiology of Pseudomonas aeruginosa - Normandie Université Access content directly
Journal Articles Microorganisms Year : 2022

Effect of Phthalates and Their Substitutes on the Physiology of Pseudomonas aeruginosa

Julien Verdon
Sophie Rodrigues
Maëliss Manac’h
  • Function : Author
Baptiste Luton
  • Function : Author
Marie Le Calvé
  • Function : Author
Alexis Bazire
Emilie Portier
  • Function : Author
Laure Taupin
  • Function : Author
Thomas Clamens
  • Function : Author
Pierre Cornelis
  • Function : Author
Jocelyne Caillon
  • Function : Author
Alain Dufour

Abstract

Phthalates are used in a variety of applications—for example, as plasticizers in polyvinylchloride products to improve their flexibility—and can be easily released into the environment. In addition to being major persistent organic environmental pollutants, some phthalates are responsible for the carcinogenicity, teratogenicity, and endocrine disruption that are notably affecting steroidogenesis in mammals. Numerous studies have thus focused on deciphering their effects on mammals and eukaryotic cells. While multicellular organisms such as humans are known to display various microbiota, including all of the microorganisms that may be commensal, symbiotic, or pathogenic, few studies have aimed at investigating the relationships between phthalates and bacteria, notably regarding their effects on opportunistic pathogens and the severity of the associated pathologies. Herein, the effects of phthalates and their substitutes were investigated on the human pathogen, Pseudomonas aeruginosa, in terms of physiology, virulence, susceptibility to antibiotics, and ability to form biofilms. We show in particular that most of these compounds increased biofilm formation, while some of them enhanced the bacterial membrane fluidity and altered the bacterial morphology.

Dates and versions

hal-03777008 , version 1 (14-09-2022)

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Cite

Mélissande Louis, Ali Tahrioui, Julien Verdon, Audrey David, Sophie Rodrigues, et al.. Effect of Phthalates and Their Substitutes on the Physiology of Pseudomonas aeruginosa. Microorganisms, 2022, 10 (9), pp.1788. ⟨10.3390/microorganisms10091788⟩. ⟨hal-03777008⟩
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