Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives
Résumé
An efficient primary amine-directed palladium catalyzed C-H halogenation (X = I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suited conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.
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