Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones
Résumé
We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of βsubstituted isoxazolidin-5-ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N-amide isoxazolidin-5-ones.
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