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              <p>L’herpèsvirus  équin  1  (HVE-1)  est  un  pathogène  majeur  chez  les équidés,responsable  de  3  formes  principales  de  maladie  :  la  forme respiratoire, la forme abortive et la forme nerveuse. Ce travail présente des  avancées  significatives  dans  le  traitement  antiviral.Une infection expérimentale de  poneys  Welsh avec la  souche  HVE-1 FR-56628 (C2254)en présence ou non de Valganciclovir a été réalisée en 2020 sur la Plate-Forme  d’Infectiologie  Expérimentale  (PFIE)  de  l’INRAe  de Nouzilly. Au cours de cette étude, menée par les équipes de LABÉO et la PFIE, l’ensemble des chevaux infectés aprésenté des signes cliniques caractéristiques des infections respiratoires à HVE-1 à des degrés divers (fièvre  &gt;  38,5°C;  jetage  nasal  ;  toux, inflammation  des ganglions, secrétions oculaires, changement de comportement).L’administration du valganciclovir  par  voie  orale  au  cours  de  notre  étude  a  permis  de maintenir uneconcentration plasmatique à un seuil comparable à celui des concentrations utilisées in  vitro. L’ensemble des effets observés en présence duvalganciclovirestactuellement en cours de soumission pour publication dès leur validation par les pairs. Ils serontprésentés de façon exhaustive dans un futur article à venir.</p>
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