Stereoselective Synthesis of Pyrrolidines from N -Allyl Oxazolidines via Hydrozirconation−Cyclization
Abstract
A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation−stereoselective Lewis acid mediated cyclization sequence.