%0 Journal Article %T Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives %+ Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA) %+ Sciences et Méthodes Séparatives (SMS) %A Martzel, Thomas %A Annibaletto, Julien %A Millet, Pierre %A Pair, Etienne %A Sanselme, Morgane %A Oudeyer, Sylvain %A Levacher, Vincent %A Brière, Jean-François %< avec comité de lecture %Z 1 %@ 0947-6539 %J Chemistry - A European Journal %I Wiley-VCH Verlag %V 26 %P 8541 %8 2020-03-11 %D 2020 %R 10.1002/chem.202001214 %K Meldrum's acid %K amino acid %K Organocatalysis %K isoxazolidinone %K asymmetric synthesis %Z Chemical Sciences/Catalysis %Z Chemical Sciences/Organic chemistryJournal articles %X A straightforward multicomponent Knoevenagel‐aza‐Michael‐Cyclocondensation reaction involving readily available hydroxamic acid‐derived from naturally occurring α‐amino acids allows a diversity‐oriented synthesis of novel isoxazolidin‐5‐ones possessing an N ‐protected α‐amino acid pendant with good to high diastereoselectivities thanks to a match effect with a chiral organocatalyst. These diversely substituted heterocycles, easily isolated as a single diastereoisomer, proved to be versatile platforms for the formation of an array of α/β‐dipeptide fragments. %G English %Z Collaboration %2 https://normandie-univ.hal.science/hal-02523950/document %2 https://normandie-univ.hal.science/hal-02523950/file/ChemEurJ2020.pdf %L hal-02523950 %U https://normandie-univ.hal.science/hal-02523950 %~ CNRS %~ INSA-ROUEN %~ COMUE-NORMANDIE %~ INC-CNRS %~ UNIROUEN %~ ENSICAEN %~ UNILEHAVRE %~ UNICAEN %~ COBRA %~ LABO-SMS %~ INSA-GROUPE %~ TEST-HALCNRS %~ ANR %~ LABOS-XL-CHEM %~ LABOS-SYNORG