%0 Journal Article %T Copy number variations in DCC/ 18q and ERBB2/ 17q are associated with disease-free survival in microsatellite stable colon cancer %+ Génétique du cancer et des maladies neuropsychiatriques (GMFC) %+ Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND) %+ Hôpital Charles Nicolle [Tunis] %+ Service de génétique [Rouen] %+ Lipides - Nutrition - Cancer (U866) (LNC) %+ Service d'Hépato-Gastroentérologie [CHU Rouen] %+ Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) %+ Service de Pathologie %+ CHU Rouen %+ Hôpital Charles Nicolle [Rouen] %+ Groupe d'étude des proliférations lymphoïdes (GPL) %+ Unité de biostatistiques [CHU Rouen] %+ Centre Guillaume le Conquérant %+ Service d'Anatomie et Cytologie Pathologique [CHU Rouen] %+ Département d'oncologie médicale [Rouen] %A Sefrioui, David %A Vermeulin, Thomas %A Blanchard, France %A Chapusot, Caroline %A Beaussire, Ludivine %A Armengol-Debeir, Laura %A Sesboüé, Richard %A Gangloff, Alice %A Hebbar, Mohamed %A Copin, Marie-Christine %A Houivet, Estelle %A Schwarz, Lilian %A Clatot, Florian %A Tuech, Jean-Jacques %A Bénichou, Jacques %A Martin, Laurent %A Bouvier, Anne-Marie %A Sabourin, Jean-Christophe %A Sarafan-Vasseur, Nasrin %A Frébourg, Thierry %A Lepage, Côme %A Michel, Pierre %A Di Fiore, Frédéric %Z IF 5.531 %< avec comité de lecture %@ 0020-7136 %J International Journal of Cancer %I Wiley %V 140 %N 7 %P 1653-1661 %8 2017-04-01 %D 2017 %R 10.1002/ijc.30584 %M 28006840 %Z Life Sciences [q-bio]Journal articles %X We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q, and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% stage II patients vs 31% stage III patients (p<0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q (p=0.012) and a gain at ERBB2/17q (p=0.041). The multivariate analysis demonstrated that stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1, or 2 alterations, respectively (p=0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in stage II-III MSS colon cancer. This article is protected by copyright. All rights reserved. %G English %L hal-02353187 %U https://normandie-univ.hal.science/hal-02353187 %~ UNIV-BOURGOGNE %~ COMUE-NORMANDIE %~ LNC-UMR866 %~ AGREENIUM %~ AGROSUP-DIJON %~ ENSBANA %~ UNIROUEN %~ GPMCND %~ TEST3-HALCNRS %~ INSTITUT-AGRO