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              <p>Les herpesvirus équins1 et 4 sont indéniablement des virus responsables de pertes économiques importantes pour  les  acteurs  de  la  filière équine. Ces  virus  sont  responsables  de  la  rhinopneumonie  équine,  qui  se caractérise   par   des   problèmes   respiratoires,   des   avortements   et   des   troubles   nerveux. À   ce   jour,la vaccination  reste  le  meilleur  moyen  de  lutte  contre  cette  maladie.  Il n’existe cependant  pas  de traitementantiviralspécifique efficace contre la  rhinopneumonie équine.Durant notre étude,nous avons évalué l’effet de  1200  moléculesissues  d’utilisationsenmédecine  humainecontre  l’HVE-1. Nous  avons  identifié  le ganciclovir  comme étant  la molécule la plus efficace contre l’HVE-1. Leganciclovirpermet d’empêcherla réplication de l’HVE-1 dès 5  μg/mLet montre,in vitro,une concentration efficace 10 fois supérieure à cellede l’aciclovir,qui est actuellementla seule molécule àavoir été utiliséesur le terrain pour soigner les formes graves  de  la  rhinopneumonie. L’effet antiviral du ganciclovir a  été  confirmé surdessouches  isolées  sur  le terrain et contre une souche d’HVE-4.  Cette étude a  permis  de mettre en évidence le très bon effet  antiviral du ganciclovir contre lesHVE-1 et HVE-4 en conditions de laboratoire</p>
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