<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02166887</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T09:35:54+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy</title>
            <author role="aut">
              <persName>
                <forename type="first">Marion</forename>
                <surname>Dalmasso</surname>
              </persName>
              <email type="md5">3458d5f7c35564b14f9e99147f731ab6</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="string">marion-dalmasso</idno>
              <idno type="idhal" notation="numeric">176202</idno>
              <idno type="halauthorid" notation="string">26242-176202</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1875-2748</idno>
              <idno type="IDREF">https://www.idref.fr/139521755</idno>
              <affiliation ref="#struct-121067"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ronan</forename>
                <surname>Strain</surname>
              </persName>
              <idno type="halauthorid">1609986-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Horst</forename>
                <forename type="middle">H.</forename>
                <surname>Neve</surname>
              </persName>
              <idno type="halauthorid">835648-0</idno>
              <affiliation ref="#struct-257151"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Charles</forename>
                <forename type="middle">M. A. P.</forename>
                <surname>Franz</surname>
              </persName>
              <idno type="halauthorid">741306-0</idno>
              <affiliation ref="#struct-233920"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <forename type="middle">J</forename>
                <surname>Cousin</surname>
              </persName>
              <email type="md5">49cfe8bea58db09250121c247f2e0dea</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="numeric">1049647</idno>
              <idno type="halauthorid" notation="string">1085956-1049647</idno>
              <affiliation ref="#struct-121067"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">R. Paul</forename>
                <surname>Ross</surname>
              </persName>
              <idno type="halauthorid">565554-0</idno>
              <affiliation ref="#struct-41137"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Colin</forename>
                <surname>Hill</surname>
              </persName>
              <idno type="halauthorid">219483-0</idno>
              <affiliation ref="#struct-434663"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marion</forename>
                <surname>Dalmasso</surname>
              </persName>
              <email type="md5">3458d5f7c35564b14f9e99147f731ab6</email>
              <email type="domain">unicaen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-06-27 11:49:19</date>
              <date type="whenModified">2026-02-26 21:36:01</date>
              <date type="whenReleased">2019-07-03 11:11:41</date>
              <date type="whenProduced">2016-06-09</date>
              <date type="whenEndEmbargoed">2019-06-27</date>
              <ref type="file" target="https://normandie-univ.hal.science/hal-02166887v1/document">
                <date notBefore="2019-06-27"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://normandie-univ.hal.science/hal-02166887v1/file/journal.pone.0156773.PDF" id="file-2166887-2161600">
                <date notBefore="2019-06-27"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.1371/journal.pone.0156773"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="563029">
                <persName>
                  <forename>Marion</forename>
                  <surname>Dalmasso</surname>
                </persName>
                <email type="md5">3458d5f7c35564b14f9e99147f731ab6</email>
                <email type="domain">unicaen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02166887</idno>
            <idno type="halUri">https://normandie-univ.hal.science/hal-02166887</idno>
            <idno type="halBibtex">dalmasso:hal-02166887</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS ONE&lt;/i&gt;, 2016, 11 (6), pp.e0156773. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0156773"&gt;&amp;#x27E8;10.1371/journal.pone.0156773&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS ONE, 2016, 11 (6), pp.e0156773. &amp;#x27E8;10.1371/journal.pone.0156773&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2166887-2161600"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Marion</forename>
                    <surname>Dalmasso</surname>
                  </persName>
                  <email type="md5">3458d5f7c35564b14f9e99147f731ab6</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="string">marion-dalmasso</idno>
                  <idno type="idhal" notation="numeric">176202</idno>
                  <idno type="halauthorid" notation="string">26242-176202</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1875-2748</idno>
                  <idno type="IDREF">https://www.idref.fr/139521755</idno>
                  <affiliation ref="#struct-121067"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ronan</forename>
                    <surname>Strain</surname>
                  </persName>
                  <idno type="halauthorid">1609986-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Horst</forename>
                    <forename type="middle">H.</forename>
                    <surname>Neve</surname>
                  </persName>
                  <idno type="halauthorid">835648-0</idno>
                  <affiliation ref="#struct-257151"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Charles</forename>
                    <forename type="middle">M. A. P.</forename>
                    <surname>Franz</surname>
                  </persName>
                  <idno type="halauthorid">741306-0</idno>
                  <affiliation ref="#struct-233920"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <forename type="middle">J</forename>
                    <surname>Cousin</surname>
                  </persName>
                  <email type="md5">49cfe8bea58db09250121c247f2e0dea</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="numeric">1049647</idno>
                  <idno type="halauthorid" notation="string">1085956-1049647</idno>
                  <affiliation ref="#struct-121067"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R. Paul</forename>
                    <surname>Ross</surname>
                  </persName>
                  <idno type="halauthorid">565554-0</idno>
                  <affiliation ref="#struct-41137"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Colin</forename>
                    <surname>Hill</surname>
                  </persName>
                  <idno type="halauthorid">219483-0</idno>
                  <affiliation ref="#struct-434663"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <idno type="eissn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">e0156773</biblScope>
                  <date type="datePub">2016-06-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0156773</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mp">Life Sciences [q-bio]/Microbiology and Parasitology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>With the emergence of multi-drug resistant bacteria the use of bacteriophages (phages) is gaining renewed interest as promising anti-microbial agents. The aim of this study was to isolate and characterize phages from human fecal samples. Three new coliphages, ɸAPCEc01, ɸAPCEc02 and ɸAPCEc03, were isolated. Their phenotypic and genomic characteristics, and lytic activity against biofilm, and in combination with ciprofloxacin, were investigated. All three phages reduced the growth of E. coli strain DPC6051 at multiplicity of infection (MOI) between 10 −3 and 10 5. A cocktail of all three phages completely inhibited the growth of E. coli. The phage cocktail also reduced biofilm formation and prevented the emergence of phage-resistant mutants which occurred with single phage. When combined with ciprofloxacin, phage alone or in cocktail inhibited the growth of E. coli and prevented the emergence of resistant mutants. These three new phages are promising biocontrol agents for E. coli infections.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-121067" status="VALID">
          <idno type="ISNI">0000 0001 2331 8773</idno>
          <idno type="ROR">https://ror.org/03265fv13</idno>
          <orgName>University College Cork</orgName>
          <orgName type="acronym">UCC</orgName>
          <desc>
            <address>
              <addrLine>College Road, Cork T12 YN60</addrLine>
              <country key="IE"/>
            </address>
            <ref type="url">http://www.ucc.ie/en/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-257151" status="INCOMING">
          <orgName>Dept Microbiol &amp; Biotechnol</orgName>
          <desc>
            <address>
              <addrLine>Kiel</addrLine>
              <country key="DE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-340092" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-233920" status="INCOMING">
          <orgName>Department of Safety and Quality of Fruit and Vegetables</orgName>
          <desc>
            <address>
              <country key="DE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356483" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-41137" status="VALID">
          <orgName>Moorepark Food Research Centre</orgName>
          <orgName type="acronym">Teagasc</orgName>
          <desc>
            <address>
              <addrLine>Moorepark, Fermoy, Co. Cork East</addrLine>
              <country key="IE"/>
            </address>
            <ref type="url">https://teagasc.ie/office/moorepark-teagasc-food-research-centre/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-337423" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-434663" status="INCOMING">
          <orgName>Alimentary Pharmabiotic Centre &amp; Microbiology Department</orgName>
          <desc>
            <address>
              <country key="IE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-121067" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-340092" status="VALID">
          <orgName>Max Rubner-Institut</orgName>
          <desc>
            <address>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.mri.bund.de/en/home/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-356483" status="INCOMING">
          <orgName>Federal Research Institute for Nutrition and Food</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-337423" status="VALID">
          <idno type="ISNI">0000000115129569</idno>
          <idno type="ROR">https://ror.org/03sx84n71</idno>
          <orgName>Irish Agriculture and Food Development Authority</orgName>
          <orgName type="acronym">Teagasc</orgName>
          <desc>
            <address>
              <addrLine>Oak Park, Carlow</addrLine>
              <country key="IE"/>
            </address>
            <ref type="url">https://teagasc.ie/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>