<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02058100</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T20:01:35+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats</title>
            <author role="aut">
              <persName>
                <forename type="first">Mounira</forename>
                <surname>Tlili</surname>
              </persName>
              <email type="md5">4f42bda06b7e383184d90c17ffe59063</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">mounira-tlili</idno>
              <idno type="idhal" notation="numeric">3581</idno>
              <idno type="halauthorid" notation="string">7662-3581</idno>
              <idno type="IDREF">https://www.idref.fr/160380642</idno>
              <affiliation ref="#struct-92263"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sonia</forename>
                <surname>Rouatbi</surname>
              </persName>
              <idno type="halauthorid">1418403-0</idno>
              <affiliation ref="#struct-301055"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Badreddine</forename>
                <surname>Sriha</surname>
              </persName>
              <idno type="halauthorid">1539003-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Khemais</forename>
                <surname>Ben Rhouma</surname>
              </persName>
              <idno type="halauthorid">1458843-0</idno>
              <affiliation ref="#struct-300754"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohsen</forename>
                <surname>Sakly</surname>
              </persName>
              <idno type="halauthorid">246946-0</idno>
              <affiliation ref="#struct-49560"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Vaudry</surname>
              </persName>
              <email type="md5">b18fa3c8c1076bb827b7a89f1a69103c</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">david-vaudry</idno>
              <idno type="idhal" notation="numeric">182015</idno>
              <idno type="halauthorid" notation="string">3246-182015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3567-7452</idno>
              <idno type="IDREF">https://www.idref.fr/123348455</idno>
              <affiliation ref="#struct-431866"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Wurtz</surname>
              </persName>
              <email type="md5">be8fc26e26881783e41339ef268ea6ea</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">olivier-wurtz</idno>
              <idno type="idhal" notation="numeric">173137</idno>
              <idno type="halauthorid" notation="string">25107-173137</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-5494-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2628-4745</idno>
              <idno type="IDREF">https://www.idref.fr/071161465</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-5494-2015</idno>
              <affiliation ref="#struct-521721"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olfa</forename>
                <surname>Tebourbi</surname>
              </persName>
              <idno type="halauthorid">1064003-0</idno>
              <affiliation ref="#struct-300754"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Olivier</forename>
                <surname>Wurtz</surname>
              </persName>
              <email type="md5">be8fc26e26881783e41339ef268ea6ea</email>
              <email type="domain">univ-rouen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-03-05 17:57:28</date>
              <date type="whenModified">2025-05-28 15:30:14</date>
              <date type="whenReleased">2019-03-05 17:57:28</date>
              <date type="whenProduced">2015</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496651"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="709522">
                <persName>
                  <forename>Olivier</forename>
                  <surname>Wurtz</surname>
                </persName>
                <email type="md5">be8fc26e26881783e41339ef268ea6ea</email>
                <email type="domain">univ-rouen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02058100</idno>
            <idno type="halUri">https://normandie-univ.hal.science/hal-02058100</idno>
            <idno type="halBibtex">tlili:hal-02058100</idno>
            <idno type="halRefHtml">&lt;i&gt;Oxidative Medicine and Cellular Longevity&lt;/i&gt;, 2015, 2015, pp.1-15. &lt;a target="_blank" href="https://dx.doi.org/10.1155/2015/787561"&gt;&amp;#x27E8;10.1155/2015/787561&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Oxidative Medicine and Cellular Longevity, 2015, 2015, pp.1-15. &amp;#x27E8;10.1155/2015/787561&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="DC2N">Différenciation et communication neuronale et neuroendocrine</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Mounira</forename>
                    <surname>Tlili</surname>
                  </persName>
                  <email type="md5">4f42bda06b7e383184d90c17ffe59063</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">mounira-tlili</idno>
                  <idno type="idhal" notation="numeric">3581</idno>
                  <idno type="halauthorid" notation="string">7662-3581</idno>
                  <idno type="IDREF">https://www.idref.fr/160380642</idno>
                  <affiliation ref="#struct-92263"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sonia</forename>
                    <surname>Rouatbi</surname>
                  </persName>
                  <idno type="halauthorid">1418403-0</idno>
                  <affiliation ref="#struct-301055"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Badreddine</forename>
                    <surname>Sriha</surname>
                  </persName>
                  <idno type="halauthorid">1539003-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Khemais</forename>
                    <surname>Ben Rhouma</surname>
                  </persName>
                  <idno type="halauthorid">1458843-0</idno>
                  <affiliation ref="#struct-300754"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohsen</forename>
                    <surname>Sakly</surname>
                  </persName>
                  <idno type="halauthorid">246946-0</idno>
                  <affiliation ref="#struct-49560"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Vaudry</surname>
                  </persName>
                  <email type="md5">b18fa3c8c1076bb827b7a89f1a69103c</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">david-vaudry</idno>
                  <idno type="idhal" notation="numeric">182015</idno>
                  <idno type="halauthorid" notation="string">3246-182015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3567-7452</idno>
                  <idno type="IDREF">https://www.idref.fr/123348455</idno>
                  <affiliation ref="#struct-431866"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Wurtz</surname>
                  </persName>
                  <email type="md5">be8fc26e26881783e41339ef268ea6ea</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">olivier-wurtz</idno>
                  <idno type="idhal" notation="numeric">173137</idno>
                  <idno type="halauthorid" notation="string">25107-173137</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-5494-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2628-4745</idno>
                  <idno type="IDREF">https://www.idref.fr/071161465</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-5494-2015</idno>
                  <affiliation ref="#struct-521721"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olfa</forename>
                    <surname>Tebourbi</surname>
                  </persName>
                  <idno type="halauthorid">1064003-0</idno>
                  <affiliation ref="#struct-300754"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">84581</idno>
                <idno type="issn">1942-0900</idno>
                <idno type="eissn">1942-0994</idno>
                <title level="j">Oxidative Medicine and Cellular Longevity</title>
                <imprint>
                  <publisher>Hindawi</publisher>
                  <biblScope unit="volume">2015</biblScope>
                  <biblScope unit="pp">1-15</biblScope>
                  <date type="datePub">2015</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1155/2015/787561</idno>
              <idno type="pubmed">26199679</idno>
              <idno type="pubmedcentral">PMC4496651</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Administration, Inhalation</classCode>
              <classCode scheme="mesh">Aerosols</classCode>
              <classCode scheme="mesh">Pituitary Adenylate Cyclase-Activating Polypeptide</classCode>
              <classCode scheme="mesh">Rats</classCode>
              <classCode scheme="mesh">Rats, Wistar</classCode>
              <classCode scheme="mesh">Real-Time Polymerase Chain Reaction</classCode>
              <classCode scheme="mesh">Respiratory Hypersensitivity</classCode>
              <classCode scheme="mesh">Tumor Necrosis Factor-alpha</classCode>
              <classCode scheme="mesh">Vanadates</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Chemokine CCL3</classCode>
              <classCode scheme="mesh">Chemokine CXCL2</classCode>
              <classCode scheme="mesh">Interleukin-1alpha</classCode>
              <classCode scheme="mesh">Lung</classCode>
              <classCode scheme="mesh">Macrophages, Alveolar</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Oxidative Stress</classCode>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.imm.ii">Life Sciences [q-bio]/Immunology/Innate immunity</classCode>
              <classCode scheme="halDomain" n="sdv.imm.ia">Life Sciences [q-bio]/Immunology/Adaptive immunology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The rate of atmospheric vanadium is constantly increasing due to fossil fuel combustion. This environmental pollution favours vanadium exposure in particular to its vanadate form, causing occupational bronchial asthma and bronchitis. Based on the well admitted bronchodilator properties of the pituitary adenylate cyclase-activating polypeptide (PACAP), we investigated the ability of this neuropeptide to reverse the vanadate-induced airway hyperresponsiveness in rats. Exposure to ammonium metavanadate aerosols (5 mg/m(3)/h) for 15 minutes induced 4 hours later an array of pathophysiological events, including increase of bronchial resistance and histological alterations, activation of proinflammatory alveolar macrophages, and increased oxidative stress status. Powerfully, PACAP inhalation (0.1 mM) for 10 minutes alleviated many of these deleterious effects as demonstrated by a decrease of bronchial resistance and histological restoration. PACAP reduced the level of expression of mRNA encoding inflammatory chemokines (MIP-1α, MIP-2, and KC) and cytokines (IL-1α and TNF-α) in alveolar macrophages and improved the antioxidant status. PACAP reverses the vanadate-induced airway hyperresponsiveness not only through its bronchodilator activity but also by counteracting the proinflammatory and prooxidative effects of the metal. Then, the development of stable analogs of PACAP could represent a promising therapeutic alternative for the treatment of inflammatory respiratory disorders.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-92263" status="VALID">
          <orgName>Laboratoire d'Informatique, de Parallélisme et de Productique</orgName>
          <orgName type="acronym">LIP2</orgName>
          <desc>
            <address>
              <addrLine>Faculté des Sciences de Tunis Université de Tunis El Manar Tunis</addrLine>
              <country key="TN"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-481790" type="direct"/>
            <relation active="#struct-207896" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301055" status="VALID">
          <idno type="IdRef">139430016</idno>
          <idno type="ISNI">0000000121144570</idno>
          <idno type="ROR">https://ror.org/00dmpgj58</idno>
          <idno type="Wikidata">Q3551673</idno>
          <orgName>جامعة سوسة = Université de Sousse = University of Sousse</orgName>
          <orgName type="acronym">USO</orgName>
          <date type="start">2004-01-01</date>
          <desc>
            <address>
              <addrLine>Rue khalifa karoui sahloul4 sousse</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">https://uso.rnu.tn/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300754" status="VALID">
          <orgName>Faculté des Sciences de Bizerte [Université de Carthage]</orgName>
          <desc>
            <address>
              <addrLine>7021 jarzouna - bizerte</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">http://www.fsb.rnu.tn/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-232921" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-49560" status="INCOMING">
          <orgName>Physiologie Intégrée</orgName>
          <desc>
            <address>
              <addrLine>Jarzouna</addrLine>
              <country key="TN"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300754" type="direct"/>
            <relation active="#struct-232921" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-431866" status="VALID">
          <orgName>International Associated laboratory Samuel de Champlain</orgName>
          <date type="start">2007</date>
          <desc>
            <address>
              <addrLine>76821 Mont-Saint-Aignan, France and Laval, H7V 1B7 Québec</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-92448" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-521721" status="OLD">
          <idno type="IdRef">159285003</idno>
          <idno type="RNSR">201019271H</idno>
          <orgName>Différenciation et communication neuronale et neuroendocrine</orgName>
          <orgName type="acronym">DC2N</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://dc2n.labos.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1239" active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation name="U1239" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-481790" status="VALID">
          <idno type="IdRef">147476275</idno>
          <orgName>Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis</orgName>
          <orgName type="acronym">FST</orgName>
          <date type="start">1960-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Tunis El Manar - Campus Universitaire El-Manar, 2092 El Manar Tunis</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">http://www.fst.rnu.tn/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-207896" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-207896" status="VALID">
          <idno type="IdRef">112859585</idno>
          <idno type="ISNI">0000000122959819</idno>
          <idno type="ROR">https://ror.org/029cgt552</idno>
          <idno type="Wikidata">Q3551684</idno>
          <orgName>Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar)</orgName>
          <orgName type="acronym">UTM</orgName>
          <date type="start">1987-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Universitaire Farhat Hached B.P. n° 94 - ROMMANA 1068 Tunis</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">http://www.utm.rnu.tn/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-232921" status="VALID">
          <idno type="IdRef">112744257</idno>
          <idno type="ISNI">0000000122953249</idno>
          <idno type="ROR">https://ror.org/057x6za15</idno>
          <orgName>Université de Carthage (Tunisie) = University of Carthage</orgName>
          <orgName type="acronym">UCAR</orgName>
          <date type="start">1988-01-01</date>
          <desc>
            <address>
              <addrLine>Avenue de la République, BP 77 - 1054 Amilcar</addrLine>
              <country key="TN"/>
            </address>
            <ref type="url">https://www.ucar.rnu.tn/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92448" status="VALID">
          <idno type="ROR">https://ror.org/04td37d32</idno>
          <orgName>Institut National de la Recherche Scientifique [Québec]</orgName>
          <orgName type="acronym">INRS</orgName>
          <desc>
            <address>
              <addrLine>490 rue de la Couronne, Québec, QC G1K 9A9</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">http://www.inrs.ca/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>