Pd-catalyzed diastereoselective trifluoromethylthiolation of functionalized acrylamides - Normandie Université Access content directly
Journal Articles Organic Letters Year : 2017

Pd-catalyzed diastereoselective trifluoromethylthiolation of functionalized acrylamides

Abstract

The Pd-catalyzed diastereoselective trifluoromethylthiolation of acrylamides was developed to allow the formation of the Z-isomer as a single product. Using a C–H bond functionalization strategy, the method was applied to a broad range of α-aryl, α-alkyl, and α,β-disubstituted acrylamides bearing the amide derived from the 8-aminoquinoline as a directing group. Mechanistic studies as well as postfunctionalization of the products were performed. This approach opens new routes to unprecedented SCF3-containing scaffolds.
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hal-02046318 , version 1 (22-02-2019)

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Qun Zhao, Thomas Poisson, Xavier Pannecoucke, J.-P. Bouillon, Tatiana Besset. Pd-catalyzed diastereoselective trifluoromethylthiolation of functionalized acrylamides. Organic Letters, 2017, 19 (19), pp.5106-5109. ⟨10.1021/acs.orglett.7b02384⟩. ⟨hal-02046318⟩
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