<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02046231</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T01:37:41+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis</title>
            <author role="aut">
              <persName>
                <forename type="first">Etienne</forename>
                <surname>Pair</surname>
              </persName>
              <idno type="idhal" notation="numeric">1516108</idno>
              <idno type="halauthorid" notation="string">906249-1516108</idno>
              <idno type="IDREF">https://www.idref.fr/190098112</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1923-5315</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Timothée</forename>
                <surname>Cadart</surname>
              </persName>
              <idno type="halauthorid">1392061-0</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Levacher</surname>
              </persName>
              <email type="md5">d6c422f8cf49226513ddef3672860144</email>
              <email type="domain">insa-rouen.fr</email>
              <idno type="idhal" notation="string">vincent-levacher</idno>
              <idno type="idhal" notation="numeric">179943</idno>
              <idno type="halauthorid" notation="string">10378-179943</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6429-1965</idno>
              <idno type="IDREF">https://www.idref.fr/083537317</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Brière</surname>
              </persName>
              <email type="md5">45643e70afdba6a98e4155d043f04bb5</email>
              <email type="domain">insa-rouen.fr</email>
              <idno type="idhal" notation="string">jean-francois-briere</idno>
              <idno type="idhal" notation="numeric">176405</idno>
              <idno type="halauthorid" notation="string">42120-176405</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/Q-8910-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1381-4535</idno>
              <idno type="IDREF">https://www.idref.fr/157793850</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Q-8910-2016</idno>
              <affiliation ref="#struct-141329"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Madeleine</forename>
                <surname>ROUX-MERLIN</surname>
              </persName>
              <email type="md5">f86e5badd714b96f2b918bacc4fba369</email>
              <email type="domain">univ-rouen.fr</email>
            </editor>
            <funder ref="#projanr-25520"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-02-22 15:37:13</date>
              <date type="whenModified">2025-05-14 11:18:15</date>
              <date type="whenReleased">2019-02-22 15:37:13</date>
              <date type="whenProduced">2016</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/WNG-N4THTZMZ-C/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="663208">
                <persName>
                  <forename>Madeleine</forename>
                  <surname>ROUX-MERLIN</surname>
                </persName>
                <email type="md5">f86e5badd714b96f2b918bacc4fba369</email>
                <email type="domain">univ-rouen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02046231</idno>
            <idno type="halUri">https://normandie-univ.hal.science/hal-02046231</idno>
            <idno type="halBibtex">pair:hal-02046231</idno>
            <idno type="halRefHtml">&lt;i&gt;ChemCatChem&lt;/i&gt;, 2016, 8 (11), pp.1882-1890. &lt;a target="_blank" href="https://dx.doi.org/10.1002/cctc.201600247"&gt;&amp;#x27E8;10.1002/cctc.201600247&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">ChemCatChem, 2016, 8 (11), pp.1882-1890. &amp;#x27E8;10.1002/cctc.201600247&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INSA-ROUEN">Institut National des Sciences Appliquées de Rouen</idno>
            <idno type="stamp" n="ENSI-CAEN">Ecole Nationale Supérieure d'Ingénieurs de Caen</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="ENSICAEN">École Nationale Supérieure d’Ingénieurs de Caen</idno>
            <idno type="stamp" n="UNILEHAVRE">Université Le Havre Normandie</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="COBRA" corresp="CNRS">Chimie Organique et Bioorganique : Reactivité et Analyse </idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="LABOS-SYNORG">Labex SYNORG</idno>
            <idno type="stamp" n="PUBLIS-SYNORG">Publications financées par le Labex SYNORG</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Etienne</forename>
                    <surname>Pair</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1516108</idno>
                  <idno type="halauthorid" notation="string">906249-1516108</idno>
                  <idno type="IDREF">https://www.idref.fr/190098112</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1923-5315</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Timothée</forename>
                    <surname>Cadart</surname>
                  </persName>
                  <idno type="halauthorid">1392061-0</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Levacher</surname>
                  </persName>
                  <email type="md5">d6c422f8cf49226513ddef3672860144</email>
                  <email type="domain">insa-rouen.fr</email>
                  <idno type="idhal" notation="string">vincent-levacher</idno>
                  <idno type="idhal" notation="numeric">179943</idno>
                  <idno type="halauthorid" notation="string">10378-179943</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6429-1965</idno>
                  <idno type="IDREF">https://www.idref.fr/083537317</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Brière</surname>
                  </persName>
                  <email type="md5">45643e70afdba6a98e4155d043f04bb5</email>
                  <email type="domain">insa-rouen.fr</email>
                  <idno type="idhal" notation="string">jean-francois-briere</idno>
                  <idno type="idhal" notation="numeric">176405</idno>
                  <idno type="halauthorid" notation="string">42120-176405</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/Q-8910-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1381-4535</idno>
                  <idno type="IDREF">https://www.idref.fr/157793850</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Q-8910-2016</idno>
                  <affiliation ref="#struct-141329"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">101575</idno>
                <idno type="issn">1867-3899</idno>
                <title level="j">ChemCatChem</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">8</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">1882-1890</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/cctc.201600247</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>For more than a hundred years, Meldrum's acid and its derivatives have proven their utility and versatility in organic synthesis. Showing very unusual properties and multiple facets of reactivity, this small architecture has become the keystone of numerous synthetic methodologies. In asymmetric organocatalysis, where the catalyst/substrate matching is of upmost importance, Meldrum's acid derivatives have slowly but surely emerged as partners of choice over the last decade. This review intends to give a comprehensive state‐of‐the‐art view of the use of Meldrum's acid in enantioselective organocatalysis. After discussing the properties of Meldrum's acid and alkylidene Meldrum's acid derivatives, we will also make a point of highlighting how they allow such a good pairing with organocatalysts.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-141329" status="OLD">
          <idno type="IdRef">147289319</idno>
          <idno type="RNSR">200012115Y</idno>
          <idno type="ROR">https://ror.org/04e8pda19</idno>
          <orgName>Chimie Organique et Bioorganique : Réactivité et Analyse</orgName>
          <orgName type="acronym">COBRA</orgName>
          <date type="start">2000-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>1 Rue Tesniere 76821 Mont St Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lab-cobra.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-106625" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-441569" type="direct"/>
            <relation active="#struct-302261" type="direct"/>
            <relation active="#struct-7127" type="indirect"/>
            <relation active="#struct-246955" type="indirect"/>
            <relation active="#struct-300317" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="FR3038" active="#struct-441569" type="direct"/>
            <relation name="UMR6014" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-106625" status="VALID">
          <idno type="IdRef">140056521</idno>
          <orgName>Institut de Chimie Organique Fine</orgName>
          <orgName type="acronym">IRCOF</orgName>
          <desc>
            <address>
              <addrLine>Rue Tesniére 76131 Mont Saint Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lab-cobra.fr/laboratoire/batiment</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301288" status="VALID">
          <idno type="IdRef">033364346</idno>
          <idno type="ISNI">0000000121908462</idno>
          <idno type="ROR">https://ror.org/020ws7586</idno>
          <orgName>Institut national des sciences appliquées Rouen Normandie</orgName>
          <orgName type="acronym">INSA Rouen Normandie</orgName>
          <date type="start">1985-01-01</date>
          <desc>
            <address>
              <addrLine>Avenue de l’Université 76801 Saint-Étienne-du-Rouvray Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-rouen.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-302261" status="VALID">
          <idno type="RNSR">200810697X</idno>
          <orgName>Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire</orgName>
          <orgName type="acronym">INC3M</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>Rue Tesnière76821 MONT ST AIGNAN CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.lcmt.ensicaen.fr/federation-inc3m/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-246955" type="direct"/>
            <relation active="#struct-300317" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-301288" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="FR3038" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-246955" status="VALID">
          <idno type="IdRef">190907991</idno>
          <idno type="ROR">https://ror.org/01fpqqe90</idno>
          <orgName>École Nationale Supérieure d'Ingénieurs de Caen</orgName>
          <orgName type="acronym">ENSICAEN</orgName>
          <desc>
            <address>
              <addrLine>6, Boulevard du Maréchal Juin CS 45053 14050 CAEN cedex 04</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ensicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300317" status="VALID">
          <idno type="IdRef">031308570</idno>
          <idno type="ISNI">0000000121731046</idno>
          <idno type="ROR">https://ror.org/05v509s40</idno>
          <orgName>Université Le Havre Normandie</orgName>
          <orgName type="acronym">ULH</orgName>
          <date type="start">1984-08-27</date>
          <desc>
            <address>
              <addrLine>25 rue Philippe Lebon - BP 1123 - 76063 Le Havre Cedex France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lehavre.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-25520" status="VALID">
          <idno type="anr">ANR-11-LABX-0029</idno>
          <orgName>SYNORG</orgName>
          <desc>Synthèse Organique : des molécules au vivant</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>