Involvement of Peptidylprolyl cis / trans Isomerases in Enterococcus faecalis Virulence - Normandie Université Access content directly
Journal Articles Infection and Immunity Year : 2012

Involvement of Peptidylprolyl cis / trans Isomerases in Enterococcus faecalis Virulence

Abstract

Peptidylprolyl cis/trans isomerases (PPIases) are enzymes involved in protein folding. Analysis of the genome sequence of Enterococcus faecalis V583 allowed for identification of 3 PPIases carrying genes. ef2898 encodes an intracellular PPIase which was not shown to be important for the E. faecalis stress response or virulence. The other two PPIases, the parvulin family rotamase EF0685 and the cyclophilin family member EF1534, are expected to be surface-exposed proteins. They were shown to be important for virulence and resistance to NaCl. A Delta ef0685 Delta ef1534 mutant was also more resistant to oxidative stress, was able to grow under a high manganese concentration, and showed altered resistance to ampicillin and quinolone antibiotics.

Dates and versions

hal-01938214 , version 1 (28-11-2018)

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Fany F. Reffuveille, Nathalie Connil, Maurizio Sanguinetti, Brunella B. Posteraro, Sylvie Chevalier, et al.. Involvement of Peptidylprolyl cis / trans Isomerases in Enterococcus faecalis Virulence. Infection and Immunity, 2012, 80 (5), pp.1728 - 1735. ⟨10.1128/IAI.06251-11⟩. ⟨hal-01938214⟩
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