Synthesis of new 4-(1-ethylthio-2,2,2-trifluoroethyl)-6-methylpyridazin-3(2H)-ones starting from S-ethyl 4-oxo-2-(pentafluoroethyl)pentanethiolate and hydrazines - Normandie Université Access content directly
Journal Articles Journal of Fluorine Chemistry Year : 2006

Synthesis of new 4-(1-ethylthio-2,2,2-trifluoroethyl)-6-methylpyridazin-3(2H)-ones starting from S-ethyl 4-oxo-2-(pentafluoroethyl)pentanethiolate and hydrazines

Abstract

The paper presents a one-pot conversion of γ-keto-α-pentafluoroethyl thioester into new pyridazin-3-ones and α,β-unsaturated lactams. The structures of all new compounds were ascribed using 1D (19F, 1H, 13C) and 2D (1H–15N) NMR data, and X-ray diffraction analysis. Two possible competitive reaction mechanisms for the synthesis of pyridazin-3-ones and lactams are presented.

Dates and versions

hal-01935486 , version 1 (26-11-2018)

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Vasile Dinoiu, Bernard Tinant, Jean-Marc Nuzillard, J.-P. Bouillon. Synthesis of new 4-(1-ethylthio-2,2,2-trifluoroethyl)-6-methylpyridazin-3(2H)-ones starting from S-ethyl 4-oxo-2-(pentafluoroethyl)pentanethiolate and hydrazines. Journal of Fluorine Chemistry, 2006, 127 (1), pp.101 - 107. ⟨10.1016/j.jfluchem.2005.11.001⟩. ⟨hal-01935486⟩
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