Antioxidant properties and bioactivity of Carboxymethylpullulan grafted with ferulic acid and of their hydrogels obtained by enzymatic reaction - Normandie Université Access content directly
Journal Articles Food Chemistry Year : 2018

Antioxidant properties and bioactivity of Carboxymethylpullulan grafted with ferulic acid and of their hydrogels obtained by enzymatic reaction

Virginie Dulong
Béatrice Labat
Didier Le Cerf
Luc Picton

Abstract

Antioxidant and cytocompatible chemically modified polysaccharides and their hydrogels were obtained by a biomimetic approach. For this purpose, carboxymethylpullulan grafted with ferulic acid (CMP-FA) was firstly synthesized with different substitution degrees (DSFA). Their hydrogels were secondly obtained by enzymatic cross-linking with laccase. Hydrogel swelling has been found dependent on both DSFA and media ionic strength. The CMP-FA antioxidant properties were evaluated by the DPPH method and ABTS assays. The DPPH radical scavenging effect was high for CMP-FA solutions (80% after 30 min) and lower for the corresponding hydrogels (70% after 7 h). The antibacterial properties of ferulic acid and CMP-FA derivatives were tested against Staphylococcus aureus but the minimal inhibitory concentration of CMP-FA was not reached in the range of concentrations studied. Finally the CMP-FA derivatives showed no cytotoxicity towards mouse fibroblast cells.
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Dates and versions

hal-01866359 , version 1 (03-09-2018)

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Virginie Dulong, Marie-Carole Kouassi, Béatrice Labat, Didier Le Cerf, Luc Picton. Antioxidant properties and bioactivity of Carboxymethylpullulan grafted with ferulic acid and of their hydrogels obtained by enzymatic reaction. Food Chemistry, 2018, 262, pp.21 - 29. ⟨10.1016/j.foodchem.2018.04.046⟩. ⟨hal-01866359⟩
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