N -benzyloxyacrylamides as bisnucleophiles in an organocatalyzed domino aza-Michael/Morita-Baylis-Hillman sequence
Résumé
We herein describe a stereoselective organocatalyzed aza-Michael/Morita-Baylis-Hillman domino reaction between readily accessible acrylamides and α,β-unsaturated carbonyls. This novel, PPh$_3$-promoted atom economic one-pot process features medium to good yields and good stereoselectivity leading to variously substituted piperidin-2-ones bearing an exocyclic olefinic bond, which was shown to be an excellent anchor for further chemical diversification.
Domaines
Chimie| Origine | Fichiers produits par l'(les) auteur(s) |
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